Abstract: Non-infectious tree diseases are physiological disorders caused by abiotic stress factors. The pathogenesis of these diseases is essentially a physiological imbalance driven by multi-factor interactions within the ecosystem. The typical symptoms of non-infectious diseases were summarized, including discoloration, necrosis, wilting, deformation, flower and fruit drop, and resin or gum exudation. The pathogenic relationships between these symptoms and chemical factors （nutrient imbalance, pesticide damage, environmental pollution and salinity） as well as physical factors （temperature extremes, water imbalance, wind damage and abnormal light conditions） were analyzed. The study elucidates how abiotic stressors compromise rhizosphere functionality and disrupt canopy photosynthetic metabolism, thereby lowering host resistance thresholds and creating entry points for pathogenic invasion. Additionally, this paper constructed diagnostic frameworks based on the chemical and physical factors contributing to tree diseases, while also investigating the temporal variation patterns of symptoms induced by nutrient deficiencies, along with the spatial distribution characteristics of their typical manifestations. For disease management, a paradigm shift from passive remediation to proactive ecosystem-based strategies is advocated, emphasizing the establishment of integrated ecosystem-resilience management frameworks to counteract compound stressors arising from climate change and anthropogenic activities.